You do not want Octoprint on a machine that is busy. Otherwise you have load spikes that cause Octoprint to not be able to send the move-commands (gcode) as fast as the printer executes the movements. This problem is pronounced with faster printers and slicers that break up arcs into small straight lines (which is practically all slicers). Otherwise your printer stutters because it has to take small breaks to wait for the next command from octoprint.